Clinical Protocols
Practical, evidence-informed resources for Long COVID & PCVS
These clinical protocols are designed to provide practical, evidence-informed guidance for healthcare providers caring for patients with Long COVID and Post-COVID Vaccine Syndrome (PCVS). Because these conditions can involve multiple overlapping systems, patients often require a comprehensive approach that addresses the underlying mechanisms, comorbidities, and individual symptom burden rather than treating each symptom in isolation.
For Clinicians
Practical clinical resources for the evaluation and management of Long COVID and Post-COVID Vaccine Syndrome.
Assess
Identify the patient's dominant symptoms, systems involved, and potential comorbidities.
Investigate
Consider appropriate diagnostic testing to identify underlying dysfunction and rule out alternative causes.
Treat
Develop an individualized treatment strategy targeting the patient's specific manifestations and underlying mechanisms.
React19
— published protocols
The Overlapping Reality
Long COVID and PCVS affect multiple systems.
/ PCVS
Patients rarely fit neatly into a single category. Recognition of overlapping conditions can be critical to appropriate evaluation and treatment.
Clinical Assessment Pathway
A systematic approach to patient evaluation and management.
History & Symptoms
Comprehensive history and symptom characterization
Physical Examination
Targeted exam to assess multiple systems
Diagnostic Testing
Identify underlying dysfunction and biomarkers
Identify Comorbidities
Common overlapping conditions
Individualized Treatment
Personalized therapy targeting root causes
Monitor Response
Track progress and adjust management
Important Note
These protocols are intended as clinical resources, not one-size-fits-all treatment plans. Evaluation and treatment should be individualized, with consideration of commonly overlapping conditions and contraindications.
Go To Studies
Each protocol includes peer-reviewed literature, clinical guidelines, and expert consensus.
Learn MoreDiagnostic Resources
Access testing recommendations, lab panels, imaging, and functional assessments used in evaluation.
View ResourcesREACT19 Provider Network
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Explore OptionsLast Updated
October 2026
Protocols are reviewed regularly to reflect the latest evidence and clinical experience.
Featured Webinars
Patient interviews and expert discussions from the React19 education library.
Have questions or comments? Reach out to us at: protocols@react19.org
Mobeen Syed, MD; Joel Wallksog, MD; Danice Hertz, MD; Jeffrey M Jones, MD; Suzanne K. Gazda, MD, Douglas H. Jones, MD, FAAAAI; Jan Maisel, MD; Phillip A. Triantos, MD; Molly Rutherford, MD; Diane Counce, MD; Elise Mecham, MD; Rehan Mehmood, MD; Madhava Sai, MD.
Clinical reference for qualified healthcare professionals only, provided for educational and informational purposes. This protocol combines guideline-supported (evidence-based), off-label, and investigational/empirical interventions, and does not constitute medical advice, establish a legal standard of care, or substitute for independent clinical judgment. All interventions require individual risk-benefit assessment and clinician supervision where applicable.
Prepared for educational and clinical-reference purposes; for use by qualified healthcare professionals only. This protocol is not a substitute for independent clinical judgment, is not reviewed or endorsed by any regulatory body, and does not establish a legal standard of care. It combines evidence-based, off-label, and investigational/empirical interventions; individual treatment plans must be tailored to patient-specific clinical factors by a licensed healthcare professional, who bears sole responsibility for treatment decisions.
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